ThromboGenics Business Update – FY 2017 15 Mar 2018 ThromboGenics Business Update – FY 2017 Advancing Preclinical and Clinical Diabetic Eye Disease Portfolio Regained global rights to JETREA® from Alcon, a Novartis company, and received €53.7 million in cash as part of the settlement agreement Total Cash & investments at €115.7 million on January 18, 2018 Highlights Pipeline •ThromboGenics continues to advance its promising pipeline of novel drug candidates for the treatment of diabetic eye disease in key areas of unmet medical need: - In December 2017, the last patient was enrolled in a Phase I/IIa study to evaluate the safety and efficacy of two dose levels of THR-317 (anti-PIGF) for the treatment of diabetic macular edema (DME). Top line results from the study are expected by end of Q1 2018. - Late stage preclinical candidates THR-149 (plasma kallikrein inhibitor) for DME and THR-687 (integrin antagonist) for diabetic retinopathy (DR) and DME continue to progress well. Both are expected to enter the clinic in 2018. - Further novel diabetic eye disease drug candidates are being studied with at least one expected to enter preclinical development in 2018. - Patient enrolment in Phase II CIRCLE Study evaluating THR-409 (ocriplasmin) for non-proliferative diabetic retinopathy (NPDR) was discontinued due to slow rate of patient recruitment. •In July 2017, ThromboGenics regained full and exclusive ownership of THR-317 for development and commercialization in all non-oncology indications as part of an amended agreement with BioInvent. As part of this amendment, BioInvent’s future royalty rate on net sales and other revenues will be 5% in all non-oncology indications. Oncurious •In September 2017, Oncurious announced an agreement with VIB to acquire a portfolio of five next generation immuno-oncology (IO) assets for the treatment of a broad spectrum of cancers. As part of this agreement, VIB has increased its equity share in Oncurious to 18.33% with the remainder being owned by ThromboGenics. •Oncurious is progressing the clinical development of TB-403 for medulloblastoma with BioInvent International. ThromboGenics and BioInvent share the costs and economic benefit of developing TB-403 for oncology indications on a 50/50 basis. JETREA® •In September 2017, ThromboGenics announced a settlement agreement by which it regained the non-US rights to JETREA® from Alcon, a Novartis company. As part of this agreement, ThromboGenics received €53.7 million in cash and a €10 million equity investment by Novartis Pharma AG. ThromboGenics now owns all rights to JETREA® globally. 2017 Appointments •Thomas Clay was elected as the new Chairman of the Board of Directors, effective June 15, 2017. Mr Clay joined the ThromboGenics Board as a non-executive in 2011. •In 2017, the Board acknowledged the resignation of Viziphar Biosciences BVBA, represented by Mr. Staf Van Reet, Innov’Activ BVBA, represented by its permanent representative Patricia Ceysens, and Lugo BVBA, represented by its permanent representative Luc Philips, as Directors of the Board. •In November 2017, ThromboGenics strengthened its leadership, welcoming two new members to the executive team: Susan Schneider, MD, was appointed Chief Medical Officer (CMO), and Vinciane Vangeersdaele was appointed Chief Commercial Officer (CCO). Financial •On January 26, 2018, the completion of an equity investment of €10 million by Novartis Pharma AG in ThromboGenics capital was confirmed as part of the settlement arrangement of September 15, 2017. Novartis Pharma AG now holds a 5.69% stake in ThromboGenics NV. The cash will be used to progress ThromboGenics’ novel diabetic eye disease pipeline. •ThromboGenics generated overall income of €9.1 million in 2017. •Inclusive of restricted cash freed up in 2018 through Novartis Pharma AG equity investment, ThromboGenics had, at the end of December 2017, €115.7 million in cash and investments, compared to €80.1 million as of the end of December 2016. Leuven, Belgium – 15 March 2018 – ThromboGenics NV (Euronext Brussels: THR), a biotechnology company developing novel medicines focused on diabetic eye disease, issues today a business update and its financial update for the year ending December 31, 2017. ThromboGenics is developing a broad pipeline of disease modifying drug candidates for the treatment of diabetic eye diseases, including: THR-317 – a PIGF neutralizing monoclonal antibody being developed for the potential treatment of DR and/or DME. Initial top-line results for the Phase I/II study in DME are anticipated to be reported by end of Q1 2018. THR-149 – a plasma kallikrein inhibitor being developed to treat DME. THR-149 is expected to enter the clinic in H1 2018. THR-687 – a small molecule integrin antagonist being developed to treat a broad range of patients with DR and/or DME. THR-687 is expected to enter the clinic around mid-2018. These products all have different modes of action and could allow the Company to address the key segments of the rapidly growing diabetic eye disease market. Further drug candidates are currently being explored for the treatment of diabetic eye disease and it is expected that at least one additional candidate will be moved into development in 2018. Patrik De Haes, MD, ThromboGenics CEO,said: “We are pleased with our progress in 2017 and expect to build further momentum during 2018. With an expected 3 clinical studies activated ahead of the summer, we are rapidly executing our ‘multiple shots on goal’ diabetic eye disease development strategy. Our strong cash position provides us with the means to achieve several value generating milestones from our pipeline of novel drug candidates over the next 12 months.”