LL schreef op 23 januari 2022 18:09:
[...]
ter aanvulling:
WHAT TREATMENT IS SUGGESTED FOR APDS?Treatment for patients with APDS depends on their individual symptoms.
Infections should be managed quickly with antibiotic (bacterial infections) or
antiviral (viral infections) drugs. If patients are at high ris k of repeated infections,
on-going antibiotic or antiviral drugs may be considered to pre vent infections
from occurring.
For patients with poor antibody production, immunoglobulin repl acement
treatment may be used. Here, immunoglobulin preparations are ta ken from the
blood and plasma of healthy donors, purified and then given to t he person with
APDS. They may be given by either intravenous (into a vein) or subcut aneous
(under the skin) injection. The aim of immunoglobulin replacement therapy is
to prevent infections and protect the person from possible furt her infections
which can result in damage to organs, such as the lungs, potent ially leading to
difficulties in breathing.
Haematopoietic stem cell transplantation (HSCT) is the only cur ative option and,
given the risks, may be considered for patients with severe APDS (including for
those who have developed a lymphoma). In HSCT, cells that grow to become
lymphocytes (called haematopoietic stem cells) are taken from a suitable healthy
donor with a good tissue match and are given to the APDS patient replacing the
abnormal haematopoietic stem cells and ultimately produce norma l immune cells
(i.e. B cells and T cells).
Some drugs (such as steroids, sirolimus or the monoclonal antib ody rituximab)
are able to modify the response of the immune system so they ar e suitable
for patients with features of autoimmunity such as low numbers of blood cells,
kidney disease, arthritis, or inflammation of the colon.
bron:
ipopi.org/wp-content/uploads/2020/06/WEB_APDS.pdf