Crucell « Terug naar discussie overzicht

RT Dinsdag 21 November 2006

277 Posts, Pagina: 1 2 3 4 5 6 ... 10 11 12 13 14 » | Laatste
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Goedendag allemaal,

Vorige week heb ik voor het eerst niet meer de draadjes bijgelezen omdat ik het niet meer “bij” kon houden, zoveel postings waren met mijn werk niet meer te combineren.

Ik kan op dit moment dan ook niets zinnigs melden wat iets toevoegt aan de kwaliteit van dit forum, alles wat er te melden is staat er al.

De cijfertjes van maandag,helaas gesloten op day low, maar wel met een bovengemiddeld volume.In de States ook bijna op day low gesloten.

AMSTERDAM
Laatste 18,45 Volume 601.203
Verschil -0,44 Verschil% -2,33%
Bied 18,43 Laat 18,45
Aantal Bieden 5.000 Aantal Laten 9.000
Dag hoog 18,80 Dag laag 18,45
Open 18,80 Slotkoers 18,89
Handelstijd 17:38 Markt Euronext Amsterdam
Jaar hoogste 24,11 Jaar laagste 13,52


NEW YORK
Laatste 23,50
Laatste volume 100
Tijd 21:58
+/- -0,56 -2,33%
Volume 47.759

Bied 00:00
Biedvolume
Laat 00:00
Laatvolume

Slot 24,06 17/11
Open 23,86 15:30
Hoog 23,86 15:42
Laag 23,47 21:55

Groet,

Truco

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Published: 07:00 21.11.2006 GMT+1 /HUGIN /Source: Crucell N.V. /AEX: CRXL /ISIN: NL0000358562

Crucell Announces Acquisition of SBL Vaccin AB and Offering of New Ordinary Shares

PRESS RELEASE

NOT FOR RELEASE, PUBLICATION OR DISTRIBUTION DIRECTLY OR INDIRECTLY IN WHOLE OR IN PART IN OR INTO THE UNITED STATES, AUSTRALIA, CANADA OR JAPAN

In any EEA Member State that has implemented Directive 2003/71/EC (together with any applicable implementing measures in any Member State, the "Prospectus Directive") this communication is only addressed to and is only directed at qualified investors in that Member State within the meaning of the Prospectus Directive. Any investor will also be deemed to have represented and agreed that any Shares acquired by it in the offer have not been acquired on behalf of persons other than such qualified investors.


Crucell Announces Acquisition of SBL Vaccin AB and
Offering of New Ordinary Shares

Leiden, The Netherlands, November 21, 2006 - Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) announced today that it has signed an agreement for the acquisition of Stockholm-based SBL Vaccin AB (SBL) from 3i and SEB for a total consideration of €39.4 million in cash. It is expected that the acquistion will be completed on Thursday, November 23, 2006.

In addition, Crucell today announced that it intends to raise €80 million through the issue of new ordinary shares. The proceeds will be used to fund the acquisition of SBL, refinance the acquisition of Berna Products Corporation completed on October 2, 2006 and repay outstanding debt of Berna Biotech AG.

Acquisition highlights:

SBL's main product Dukoral® is a market leading oral vaccine against cholera, which will further expand and strengthen Crucell's travel vaccines franchise
The acquisition further strengthens Crucell's sales organization in Scandinavia
SBL generated approximately €25.2 million in revenues in 2005, EBIT amounted to €2.6 million and cash flow was €0.6 million
Through Q3 of 2006 SBL generated €17.6 million in revenues, €0.5 million in EBIT and €2.7 million in cash flow

SBL is a fully integrated independent Swedish biotechnology company employing 120 people. SBL's main product is Dukoral®, an oral vaccine which offers protection against cholera and is registered in more than 50 countries excluding the US. Dukoral® is also registered in the same countries (excluding the EU and Australia) to protect against ETEC (travelers' diarrhea). Sales have increased by more than 60% since 2004. In 2005 sales exceeded €14 million (SEK 125 million).

In addition, SBL is the leading sales and distribution organization for vaccines in Scandinavia. The company markets a broad range of vaccines sourced from global vaccine companies including Crucell. Revenues related to the distribution of third party products amounted to approximately €11 million (SEK 100 million) in 2005.

Revenues for the nine-month period ended September 30, 2006 amount to €17.6 million. EBIT for the nine months ended September 30, 2006 amount to €0.5 million, compared to €2.6 million for the full year 2005. The 2006 EBIT reflects seasonality and mix in revenue patterns. Cash flow for the nine-month period ended September 30, 2006 amount to €2.7 million and include certain one-time payments. Cash flow for full year 2005 was €0.6 million.

Crucell acquired Berna Products Corporation, now part of Crucell Vaccine Inc., in the US on October 2, 2006. The acquisition of SBL further expands Crucell's global sales reach and strengthens its sales organization through SBL's strong presence in the Scandinavian markets. Furthermore, SBL's main product, Dukoral®, strengthens Crucell's portfolio of travel vaccines, which includes Epaxal® and Vivotif®.

"The acquisitions of SBL and Berna Products Corporation both fit perfectly in our strategy to further expand our travel vaccines portfolio," said Crucell's CEO Ronald H.P. Brus. "We now have access to 'best in class' marketing & sales capabilities, which we will use to accelerate future sales growth and support new product launches."

Equity offering
In conjunction with the acquisition of SBL, Crucell intends to raise €80 million through the issue of new ordinary shares. The proceeds of the offering will be used for:
Funding the acquisition of SBL (€39.4 million)
Refinancing the acquisition Berna Products Corporation (€14 million) including related costs
Repayment of outstanding mortgage loans held in Berna Biotech AG (€19 million)
Additional proceeds (net of transaction costs) will be used for general corporate purposes

The issue of new ordinary shares will be executed by way of an accelerated book built offering ("Offering") to be launched immediately following this announcement. Based on the closing price of Crucell shares on Euronext Amsterdam on Monday, November 20, 2006 of €18.45, an €80 million equity issue would result in the issue of approximately 4.3 million new shares, representing approximately 7.3% of the current outstanding share capital of Crucell. The Offering will be structured as a private placement of shares in the Netherlands and elsewhere, subject to restrictions, to eligible institutional investors only.

ABN AMRO Rothschild will be conducting the Offering as sole lead manager and bookrunner. The bookbuilding process is expected to close by the end of business on November 21, 2006, but may be closed earlier or later at the discretion of ABN AMRO Rothschild.

The Offering is conditional upon the admission of the new ordinary shares to listing and trading on Euronext Amsterdam N.V.'s Eurolist by Euronext and certain other customary conditions. Application for admission to listing and trading will be made. Barring unforeseen circumstances, it is currently expected that settlement of the Offering will take place on Friday, November 24, 2006.

The issue of new ordinary shares is not conditional upon closing of the acquisition or the approval of Crucell's shareholders. If the acquisition of SBL is not completed, proceeds from the equity offering will be used for general corporate purposes.

On the assumption that the equity offering is completed, Crucell has undertaken not to issue any additional shares for a period of 180 days, subject to exceptions customary in offerings of this nature.

No prospectus has been or will be published in connection with the placing of the new ordinary shares. The number of shares to be included in the equity issue will be less than 10% of the total of 59.4 million outstanding shares of Crucell as of November 21, 2006.

When issued, the new ordinary shares will rank pari passu in all respects with Crucell's existing issued ordinary shares.

Outlook
Crucell published its third quarter results on November 14, 2006 and held an Analyst Meeting on November 16, 2006. Crucell narrowed the range for its revenue guidance for the year, which it now expects to be in the €140 million to €150 million range. Fourth quarter revenues are expected to be strong due to strong influenza vaccine sales, which are concentrated in the fourth quarter due to the late start of the influenza season this year. Moreover, sales of its new Quinvaxem(TM) pediatric vaccine have first started in October 2006. The total decrease in cash over 2006, excluding the cash acquired in the Berna Biotech
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Fourth quarter revenues are expected to be strong due to strong influenza vaccine sales, which are concentrated in the fourth quarter due to the late start of the influenza season this year. Moreover, sales of its new Quinvaxem(TM) pediatric vaccine have first started in October 2006. The total decrease in cash over 2006, excluding the cash acquired in the Berna Biotech acquisition on February 22, 2006, was expected to be in the range of €33 million to €38 million. The Company aims to achieve cash break even in 2007.

Conference Call and Webcast
Crucell will conduct a conference call today, November 21, 2006, starting at 10:00 am Central European Time. A presentation regarding the acquisition of SBL will be followed by a question and answer session. To participate in the conference call, please call the following number within 10 minutes prior to commencement:

+31 (0)45-631 6901

The conference call will also be webcast. The live audio webcast can be accessed via the homepage of Crucell's website at www.crucell.com, and will be archived and available for replay following the event.

About Crucell
Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a biotechnology company focused on research, development and worldwide marketing of vaccines and antibodies that prevent and treat infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell's core portfolio includes a vaccine against hepatitis B, a fully-liquid vaccine against five important childhood diseases, and a virosome-adjuvanted vaccine against influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine and the only aluminum-free hepatitis A vaccine on the market. The Company has a broad development pipeline, with several Crucell products based on its unique PER.C6® production technology. The Company licenses this and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, sanofi aventis, GSK and Merck & Co. Crucell is headquartered in Leiden (the Netherlands), with subsidiaries in Switzerland, Spain, Italy, Korea and the US. The Company employs about 900 people. For more information, please visit www.crucell.com.

Restrictions
These materials are for information purposes only and are not intended to constitute, and should not be construed as, an offer to sell or a solicitation of any offer to buy the securities of Crucell N.V. (the "Issuer", and such securities, the "Securities") in the United States, or to or for the benefit of US persons (as such term is defined in Regulation S of the US Securities Act of 1933, as amended (the "US Securities Act")) or in any other jurisdiction in which such offer, solicitation or sale is not authorised or to any person to whom it is unlawful to make an offer or solicitation, and the distribution of this communication in such jurisdictions may be restricted. Persons into whose possession this communication comes should inform themselves about and observe any such restrictions. Any failure to comply with these restrictions may constitute a violation of the securities laws of any such jurisdiction.

The Securities have not been and will not be registered under the Securities Act and may not be offered or sold in the United States absent registration or an exemption from registration under the US Securities Act. No portion of the Securities will be registered, and there will be no public offering of Securities, in the United States.

This document is only being distributed to and is only directed at: (i) persons who are outside the United Kingdom to whom it may lawfully be distributed; or (ii) investment professionals falling within Article 19(5) of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2005 (the "Order"); or (iii) high net worth entities, and other persons to whom it may lawfully be communicated, falling within Article 49(2)(a) to (d) of the Order (all such persons together being referred to as "Relevant Persons"). The Securities are only available to, and any invitation, offer or agreement to subscribe, purchase or otherwise acquire such securities will be engaged in only with, Relevant Persons. Any person who is not a Relevant Person should not act or rely on this document or any of its contents.

Forward-looking statements
This press release contains forward-looking statements that involve inherent risks and uncertainties. We have identified certain important factors that may cause actual results to differ materially from those contained in such forward-looking statements. For information relating to these factors please refer to our Form 20-F, as filed with the U.S. Securities and Exchange Commission on July 6, 2006, and the section entitled "Risk Factors". The Company prepares its financial statements under generally accepted accounting principles in the United States (US GAAP) and Europe (IFRS).

For further information please contact:

Crucell N.V.
Leonard Kruimer
Chief Financial Officer
Tel. +31 (0)71 524 8722
l.kruimer@crucell.com
Paul Vermeij
Director Investor Relations and Corporate Communications
Tel. +31 (0)71 524 8718
p.vermeij@crucell.com



PDF file

Voor meer informatie over Crucell, bezoek onze website: www.crucell.com

Als u niet langer Crucell persberichten wenst te ontvangen, kunt u zich uitschrijvende via onderstaande link: cws.huginonline.com/C/132631/unsubscr...

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Amsterdam (BETTEN BEURSMEDIA NEWS) - Crucell neemt het Zweedse vaccinbedrijf SBL Vaccin over van 3i en SEB voor EUR 39,4 miljoen. Dat heeft het Leidse biotechnologiebedrijf dinsdag bekendgemaakt. Crucell laat verder weten EUR 80 miljoen te willen ophalen met de uitgifte van nieuwe aandelen.

Met dit geld wil het bedrijf de overname van SBL betalen, de in oktober van dit jaar afgeronde acquisitie van Berna Products Corporation herfinancieren en de uitstaande schuld van Berna Biotech afbetalen.

SBL is gevestigd in Stockholm en telt 120 medewerkers. Het belangrijkste product van het bedrijf is Dukoral, een oraal vaccin tegen cholera. Met dit vaccin is SBL volgens Crucell markleider.

Cholera is een infectieziekte die wordt veroorzaakt door de Vibrio cholerae-bacterie. Het belangrijkste kenmerk van de ziekte is ernstige diarree en uitdroging.

Met de acquisitie versterkt Crucell naar eigen zeggen zijn zogenoemde reisvaccin-afdeling en daarnaast de sales-organisatie is Scandinavie. Over 2005 realiseerde SBL een bedrijfsresultaat (ebit) van EUR 2,6 miljoen op een omzet van ruim EUR 25 miljoen. De kasstroom bedroeg toen EUR 0,6 miljoen.

In het derde kwartaal van dit jaar kwam de omzet van SBL uit op 17,6 miljoen, werd een bedrijfsresultaat van EUR 0,5 miljoen geboekt en bedroeg de kasstroom EUR 2,7 miljoen.
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by way of an accelerated book built offering ("Offering") to be launched immediately following this announcement.

Wat betekent dit?

Er zitten nog meer konijnen in de hoge hoed. De strategie om via sales de komende jaren te overbruggen krijgt steeds meer gestalte.

4.3 mio aandeeltjes erbij.
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Leuk gegeven voor josti5 (John):

The Offering will be structured as a private placement of shares in the Netherlands and elsewhere, subject to restrictions, to eligible institutional investors only.

Lijkt mij een goede deal. Hierop zal de koers zeker reageren. Wat een nieuws zeg. Aanbevolen!
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Past dus mooi in de combination vaccingedachte.

Swedish company SBL Vaccin AB brought on-line in the second quarter of 2003 a major extension and upgrade to its vaccine production facility at Solna near Stockholm. The company was until recently a subsidiary of Powderject PLC, which acquired the company in a $50 million deal in 2001. Powderject PLC merged with the US vaccine manufacturer Chiron Inc in May 2003. The SBL Vaccin name is to be retained and products marketed under the brand name in Europe and Asia.

The extension to the Solna plant was started in the first quarter of 2002 and required an investment of $7.5 million from the parent company Powderject PLC. The new extension is to increase the production of cholera vaccine at the facility. The cholera vaccine produced in Solna is the only one that has full World Health Organisation (WHO) recommendation. The cholera vaccine is to be incorporated into a new combination vaccine product aimed at the travel market.
CHOLERA VACCINE FACILITY CONTRACTORS

The contract for basic engineering and design of the plant, including a biosafety level three production area, was awarded to Elomatic Pharmaceutical Engineering of Finland. The contract for the design, engineering, control and automation of the bioreactors and associated downstream processing was awarded to Belach Bioteknik AB of Sweden. The control and automation system software and IT was provided by Wonderware Scandinavia. Software systems to integrate the production plant with the sales and distribution side of the business were provided by Jeeves (Sweden) in collaboration with ISE Konsult.
VACCINE PRODUCTION PLANT

The vaccine production takes place in three different buildings at the plant. The first is the bulk solution preparation building, where media preparation and bulk solution preparation for diafiltration and cleaning are carried out. The second building houses the wastewater inactivation system, where all process solutions are collected, monitored, pH adjusted and inactivated. The third building houses the four bioreactors used for bacterial stem cultivation and also inactivation process vessels and ultrafiltration equipment.

The vaccine production process begins with frozen cholera stems; these are thawed and inoculated to the bioreactors containing bulk media. Fermentation is followed by downstream processing. This includes ultrafiltration to remove debris and aggregated material and bacterial inactivation or attenuation by using heat or treatment with a formaldehyde solution. Several washing and filtration steps are followed by transfer to a sterile container and cold room storage. The vaccine can then pass to a fill and finish line to be dispensed and packaged.
TECHNOLOGY

Since the operation cultivates a bacterium which is highly hazardous to human health the plant is highly automated, making use of Wonderware's InControl, InBatch, InTouch and FactorySuite software systems. The InBatch system is designed to run parallel batches in four inactivation vessels to collate all of the batch related information, including operator information, material tracking data and process parameters, and to control each batch process.

The batch control and automation system satisfies FDA 21 CFR Part 11 and also Good Automated Manufacturing Practice (GAMP) guidelines. The bulk solution preparation areas and waste inactivation areas are largely software-controlled in continuous mode operation with little operator activity. The plants may be observed remotely in a control room area.
SOFTWARE

InControl is the software that provides basic and sequential control and also phase logic; this is the software that controls the equipment. InTouch is the software that provides the Human Machine Interface (HMI); this allows the operators to access process control parameters and process data in a user-friendly graphical format in real time. InBatch is the batch management software, controlling not only batch processes but also logging all the pertinent data for each batch for a reliable, foolproof tracking system.

Belack Bioteknik specialise in the design, construction and installation of highly automated bioreactor systems for biotech applications. They have also made automation improvements to the polio production system at SBL Vaccin during 2003. The cholera production capacity is seven times greater than before the expansion.
DUKORAL COMBINATION VACCINE DRINK

The new expansion at Solna is to concentrate on the production of Dukoral, a combination vaccine drink. The vaccine will protect against enterotoxigenic E. Coli (ETEC), a major cause of diarrhoea for travellers, and also cholera, a major risk in under-developed countries caused by contaminated food and water. The worldwide travel diarrhoea vaccine market is estimated to be worth in the order of $400 million by 2005. The oral dosage regimen of this product is very convenient and because of this it is currently being supplied to African and Latin American countries where cholera is a problem on the recommendation of the WHO. Dukoral has not yet been approved by the FDA for the US market.

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RTRS-Crucell neemt Zweedse vaccinmaker over
LEIDEN (ANP) - Het biotechnologiebedrijf Crucell neemt de
Zweedse vaccinproducent SBL Vaccin over voor 39,4 miljoen euro.
Dat heeft het bedrijf dinsdag bekendgemaakt.

De Leidse onderneming wil 80 miljoen euro ophalen met de
uitgifte van nieuwe aandelen. De opbrengst wordt gebruikt voor
de overnames van SBL en Berna Products Corporation en voor de
aflossing van schulden die voortkwamen uit de acquisitie van
Berna Biotech.

((ANP Redactie Economie, email economie(at)anp.nl, +31 20
504 5999))
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quote:

wilb52 schreef:

Nu is ook duidelijk waarom de koers TERUG MOEST vanaf de 20

sammie
Inderdaad sammie, de aap komt uit de mouw!

The issue of new ordinary shares will be executed by way of an accelerated book built offering ("Offering") to be launched immediately following this announcement. Based on the closing price of Crucell shares on Euronext Amsterdam on Monday, November 20, 2006 of €18.45, an €80 million equity issue would result in the issue of approximately 4.3 million new shares, representing approximately 7.3% of the current outstanding share capital of Crucell. The Offering will be structured as a private placement of shares in the Netherlands and elsewhere, subject to restrictions, to eligible institutional investors only.
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Ik hoor goed nieuws, ik lees een fikse verwatering. Lijkt me geen goed nieuws, iemand hier een uitgesproken onderbouwde mening over?

Straks nog eens op het gemak doorlezen... Voelde niet goed toen ik het net las eerlijk gezegd.

Overnameprijs 2,2 x de omzet of 15x de ebit, lijkt me vrij prijzig ook al zitten er goede marges op de producten en zal er natuurlijk wat verdient kunnen worden op synergievoordelen. Kon even geen vergelijkingsmateriaal vinden helaas.
$rob$
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quote:

wilb52 schreef:

Nu is ook duidelijk waarom de koers TERUG MOEST vanaf de 20

sammie
Misschien een domme vraag van mij, maar waarom moet de prijs altijd naar beneden als er een overname op komst is. Als de prijs per aandeel hoger is hoef je als bedrijf toch minder aandelen uit te geven om hetzelfde bedrag binnen te halen, voor overname o.i.d. Hoe lager de pps, hoe meer aandelen je moet uitgeven en is de verwatering toch groter. Wie kan mij dat uitleggen?
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eerst wellicht even de eerste schrik verwerken, dan vet omhoog:

""..to eligible institutional investors only. ""

De nieuwe aandelen worden dus uitgezet aan institutionele beleggers, die staan echt al in de rij hoor.
Geeft zeer veel vertrouwen, zie ook de discussie gisteravond met Josti.
Dit is precies wat we nodig hebben.
Doordat institutionele beleggers ""preferent""gaan instappen (zoals bv pensioenfondsen e.d.) creert men een massieve bodem onder het bedrijf.
Die verkopen nl niet zo snel!
Great news!
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quote:

rschilders schreef:

[quote=wilb52]
Nu is ook duidelijk waarom de koers TERUG MOEST vanaf de 20

sammie
[/quote]

Misschien een domme vraag van mij, maar waarom moet de prijs altijd naar beneden als er een overname op komst is. Als de prijs per aandeel hoger is hoef je als bedrijf toch minder aandelen uit te geven om hetzelfde bedrag binnen te halen, voor overname o.i.d. Hoe lager de pps, hoe meer aandelen je moet uitgeven en is de verwatering toch groter. Wie kan mij dat uitleggen?
De aandelen moeten ook een keer worden verkocht he ;-) misschien is de 18.45 wel een erg mooie prijs daarvoor geweest of gebleken bij onderzoek.
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Nu word ook duidelijk dat er geen verschil is tussen Sopheon , Antonov en CruSELL. Allen zijn alleen goed in verlies maken en aandelen bijdrukken...

AArrggg. Strong Sell.
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ik zie maar een paar grote verkopers/handelaren, die willen even profiteren van de daling, ik raad sterk aan je aandelen vast te houden, want we gaan later zeker stijgen.
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Ik vind groeien prima, zeker voor de lange termijn. Mij bekruipt nu wel het gevoel dat de regisseur van de koers, rond de 18,50, Crucell zelf is geweest. Vandaar de slechte geen nieuws show in Amerika.
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quote:

yellowww. schreef:

Nu word ook duidelijk dat er geen verschil is tussen Sopheon , Antonov en CruSELL. Allen zijn alleen goed in verlies maken en aandelen bijdrukken...

AArrggg. Strong Sell.
Oppassen, he. We hebben nu een vaccin tegen yellow fever!!
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